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Glutathione S-Transferases Structure, Function and Clinical Implications

Melissa D. Figures References Related Details Cited By Glutathione-related substances maintain cardiomyocyte contractile function in hypoxic conditions. Production of adeno-associated virus vectors for in vitro and in vivo applications. BBE31 from the Lyme disease agent Borrelia burgdorferi, known to play an important role in successful colonization of the mammalian host, shows the ability to bind glutathione. Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation.

Dietary CCPS from bitter gourd attenuates sodium arsenite induced female reproductive ailments cum infertility in wistar rats: anti-inflammatory and anti-apoptotic role.

Reactive oxygen, nitrogen, and sulfur species in human male fertility. A crossroad of cellular signaling and pathology. Olga Gorelenkova Miller and John J.

Intro to Glutathione - Masterclass With Masterjohn 1.6

Green olive leaf extract OLE provides cytoprotection in renal cells exposed to low doses of cadmium. Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways. Mitochondrial dynamics in exercise physiology. Targeting glutathione S-transferase P and its interactome with selenium compounds in cancer therapy. Cysteine allows ovarian cancer cells to adapt to hypoxia and to escape from carboplatin cytotoxicity. SMYD2 glutathionylation contributes to degradation of sarcomeric proteins. Attenuation of utero-toxicity, metabolic dysfunction and inflammation by soy protein concentrate in rats exposed to fluoridated water: consequence of hyperlipidemia in parallel with hypohomocysteinemia.

Pyrethroid bifenthrin induces oxidative stress, neuroinflammation, and neuronal damage, associated with cognitive and memory impairment in murine hippocampus. Involvement of metallothionein, homocysteine and B-vitamins in the attenuation of arsenic-induced uterine disorders in response to the oral application of hydro-ethanolic extract of Moringa oleifera seed: a preliminary study.

Restoration of uterine redox-balance by methanolic extract of Camellia sinensis in arsenicated rats. Nitric oxide in frozen-thawed equine sperm: Effects on motility, membrane integrity and sperm capacitation. Reducing protein oxidation reverses lung fibrosis. Seleno-short-chain chitosan induces apoptosis in human breast cancer cells through mitochondrial apoptosis pathway in vitro.

Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle. The role of nitric oxide in diabetic skin patho physiology. Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies. Role of thiols in oxidative stress. The consequence of NAC on sodium arsenite-induced uterine oxidative stress. Seleno-short-chain chitosan induces apoptosis in human non-small-cell lung cancer A cells through ROS-mediated mitochondrial pathway. GSTO plays a pro-inflammatory role in models of inflammation, colitis and obesity.

Marcel Deponte. Contribution of glutaredoxin-1 to S-glutathionylation of endothelial nitric oxide synthase for mesenteric nitric oxide generation in experimental necrotizing enterocolitis. Redox regulation of ischemic limb neovascularization — What we have learned from animal studies. Oxidative stress in Duchenne muscular dystrophy: focus on the NRF2 redox pathway. Dysfunction of mitochondrial Lon protease and identification of oxidized protein in mouse brain following exposure to MPTP: Implications for Parkinson disease.

Combined l -citrulline and glutathione administration prevents neuronal cell death following transient brain ischemia. Modulation of the specific glutathionylation of mitochondrial proteins in the yeast Saccharomyces cerevisiae under basal and stress conditions. From structure to redox: The diverse functional roles of disulfides and implications in disease. The role of sulfenic acids in cellular redox signaling: Reconciling chemical kinetics and molecular detection strategies.

Glutathionylation of chikungunya nsP2 protein affects protease activity.


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A possible S-glutathionylation of specific proteins by glyoxalase II: An in vitro and in silico study. Proteomic approaches to quantify cysteine reversible modifications in aging and neurodegenerative diseases. Review of RyR1 pathway and associated pathomechanisms. Sarah L. Short , Sina Tavakoli , Susan T. Weintraub , Kevin Downs , and Reto Asmis. John D. Prediction of glutathionylation sites in proteins using minimal sequence information and their experimental validation.

Relevance of peroxynitrite formation and 3-nitrotyrosine on spermatozoa physiology. Grazia Tamma and Giovanna Valenti. The adaptive metabolic response involves specific protein glutathionylation during the filamentation process in the pathogen Candida albicans. Quantitative measures for redox signaling.

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Identification of S-glutathionylation sites in species-specific proteins by incorporating five sequence-derived features into the general pseudo-amino acid composition. S -Glutathionylation of Keap1: a new role for glutathione S -transferase pi in neuronal protection.

Mixed results with mixed disulfides. Carbohydrate polymer inspired silver nanoparticles for filaricidal and mosquitocidal activities: A comprehensive view. Clickable glutathione using tetrazine-alkene bioorthogonal chemistry for detecting protein glutathionylation. Glutathionyl systems and metabolic dysfunction in obesity. Hydrogen peroxide — production, fate and role in redox signaling of tumor cells. Glutathione-S-transferase omega 1 GSTO acts as mediator of signaling pathways involved in aflatoxin B1-induced apoptosis—autophagy crosstalk in macrophages.

Signaling and stress: The redox landscape in NOS2 biology. The Redox Code. Dean P. Jones and Helmut Sies. Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases.

Redox signaling, Nox5 and vascular remodeling in hypertension. Thiol redox homeostasis in neurodegenerative disease. The roles of glutaredoxins ligating Fe—S clusters: Sensing, transfer or repair functions? Elephantopus scaber induces apoptosis through ROS-dependent mitochondrial signaling pathway in HCT human colorectal carcinoma cells. Post-translational modifications disclose a dual role for redox stress in cardiovascular pathophysiology. Auranofin-induced oxidative stress causes redistribution of the glutathione pool in Taenia crassiceps cysticerci.

Oxidized glutathione GSSG inhibits epithelial sodium channel activity in primary alveolar epithelial cells. Redox regulation by reversible protein S-thiolation in bacteria. Glutaredoxin deficiency exacerbates neurodegeneration in C. New insights into male in fertility: the importance of NO. S-nitrosation and neuronal plasticity.

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The glutaredoxin mono- and di-thiol mechanisms for deglutathionylation are functionally equivalent: implications for redox systems biology. Homocysteine in Chronic Kidney Disease.

Glutathione S-Transferases: Structure, Function and Clinical Implications

PGluS: prediction of protein S-glutathionylation sites with multiple features and analysis. Reversible redox modifications in the microglial proteome challenged by beta amyloid. Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS. The ability of cells to adapt to low-oxygen conditions is associated with glutathionylation of Na,K-ATPase. Dysregulation of Glutathione Synthesis in Psychiatric Disorders. Chemical-proteomic strategies to investigate cysteine posttranslational modifications.

Regulated spatial organization and sensitivity of cytosolic protein oxidation in Caenorhabditis elegans. Redox metabolism in Trypanosoma cruzi. Biochemical characterization of dithiol glutaredoxin dependent cellular pathways. Well-defined polymer-drug conjugate engineered with redox and pH-sensitive release mechanism for efficient delivery of paclitaxel.


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Thioredoxin-1 redox signaling regulates cell survival in response to hyperoxia. Protein S -glutathionylation: from current basics to targeted modifications. Redox regulation of endothelial cell fate. Glutaredoxin1 protects neuronal cells from copper-induced toxicity. Reassessing cellular glutathione homoeostasis: novel insights revealed by genetically encoded redox probes.

Glutathione S-Transferases | Structure, Function and Clinical Implications | Taylor & Francis Group

Nitration and Nitrosylation. Disulfide stress: a novel type of oxidative stress in acute pancreatitis. Antioxidant gene therapy against neuronal cell death.